PROF DORCAS SYOKUI YOLE


POSITION
CURRENT DESIGNATION: PROFESSOR
OFFICE EMAIL: dyole@tukenya.ac.ke
OFFICE TELEPHONE: +254(020) 2219929, 3341639, 3343672
CONSULTATION HOURS: 8AM-5PM MON - FRI
no photo
EDUCATION
Qualification Area of Specialization Institution Year
DOCTOR OF PHILOSOPHY (PHD)DOCTOR OF PHILOSOPHY IN BIOLOGYUNIVERSITY OF YORK (UNITED KINGDOM)1995
MASTERS OF SCIENCE (M.SC.)MASTER OF SCIENCE (IN PARASITOLOGY)UNIVERSITY OF NAIROBI (KENYA)1892
BACHELOR OF SCIENCE (BSC)BACHELOR OF SCIENCEUNIVERSITY OF NAIROBI (KENYA)1986
CERTIFICATEEAST AFRICA ADVANCE CERTIFICATE OF EDUCATIONPRECIOUS BLOOD SECONDARY SCHOOL KILUNGU (KENYA)1979
CERTIFICATEKENYA ADVANCE CERTIFICATE OF EDUCATIONALLIANCE GIRLS HIGH SCHOOL (KENYA)1981
WORK EXPERIENCE
Period Position Institution
2014 - TO DATEPROFESSOR AT DEPARTMENT OF APPLIED AND TECHNICAL BIOLOGYTUK (KENYA)
GENERAL STATEMENT ON RESEARCH AREA(S)
My areas of research interests are : Vaccine development in Schistosomiasis,Drug development for Schistostosomiasis based on herbal extracts,Development of molluscicides against the snail intermediate host of Schistosoma based on herbal extracts,Integrated approach in control of neglected parasites and Co-infections
SELECTED PUBLICATIONS
- Okonjo Edward, Yole Dorcas, Eric Korir, Nguu Edward, Anyango Beatrice and Ogoyi Dorington (2015). Detection of proteins induced in the haemolymph of Biomphalaria pfeifferi infected with Schistosoma mansoni. Journal of Applied Bioscience 88:8211-8222.
http://www.ajol.info/index.php/jab/article/view/117646
- Kennedy Muna Kuria, Dorcas Yole and Mbaruk Abdalla Suleiman (September, 2015). Brine Shrimp Lethality Test of Soluble Proteins from Biomphalaria pfeifferi Snail as Preliminary for Vaccine Development Schistosoma mansoni. American International Journal of Research in Science, Technology, Engineering and Mathematics. pp 104-107. ISSN (Online) 2328-3580)
https://www.academia.edu/15788797/Brine_Shrimp_Lethality_Test_of_Soluble_Proteis_from_Biomphalaria_pfeifferi_Snail_as_Preliminary_for_Vaccine_Development_for_Schistosoma_mansoni
- Elizabeth Syombua Michael, Dorcas Yole, Mutie Fredick Musila, Hellen Kutima, Patrick Kareru (2013). Assessment of molluscidal, Cercaricidal and Miracidial Activities of Crude Extracts of Azadirachta indica and Entada leptostachya. Journal of Biology, Agriculture and Healthcare. Vol.3. No.5 http://www.iiste.org/Journals/index.php/JBAH/article/view/5363
- Kennedy Muna Kuria, Dorcas Yole and Mbaruk Abdalla Suleiman (September, 2015). Brine Shrimp Lethality Test of Soluble Proteins from Biomphalaria pfeifferi Snail as Preliminary for Vaccine Development Schistosoma mansoni. American International Journal of Research in Science, Technology, Engineering and Mathematics. pp 104-107. ISSN (Online) 2328-3580) https://www.academia.edu/15788797/Brine_Shrimp_Lethality_Test_of_Soluble_Proteis_from_Biomphalaria_pfeifferi_Snail_as_Preliminary_for_Vaccine_Development_for_Schistosoma_mansoni
- Moilo J.M., Keriko J.M., Yole D.S. & Mkoji G.M. (2014). Determination of Anti-schistosomal Finger Profiles of Chenopodium ambrosoides Crude Extracts in BALB/c Mice Using Thin Layer Chromatography (TLC). Journal of Chemistry and Material Research. Paper accepted for publication
http://www.iiste.org/Journals/index.php/CMR/article/view/13455
- Allan L.A., Kutima H.L., Muya S., Ayonga D. & Yole D. (2014). The efficacy of a herbal drug, Schitozim over Praziquantel in management of Schistosoma mansion infection in BALB/c mice. Journal of Biology, Agriculture and Health. Vol. 4(1). http://www.primateresearch.org/index.php/component/content/article/30-research-scientists/41-dr-dorcas-s-yole
- Naomi Waiganjo, Yole D, Ochanda H (2014). Immunological Responses of Mice after Treatment with Ocimum americanum hexane and Bridelia micrantha Water Plant Extracts. IORS Journal of Dental and Medical Sciences. Vol.13 (3):9-12 http://www.iosrjournals.org/iosr-jdms/papers/Vol13-issue3/Version-5/C013350912.pdf
- Naomi Waiganjo, Horace Ochanda, Dorcas Yole (2013). Phytochemical analysis of the selected five plant extracts. Chemistry and Materials Research. Vol. 3 No.9. http://pakacademicsearch.com/pdf-files/eng/454/12-17%20Vol%203,%20No%209%20%282013%29.pdf
- Kennedy Muna Kuria, Rebecca Waihenya and Dorcas Yole. (2012) Cellular responses against S. mansoni in immunized Balb/C mice with soluble proteins from foot and digestive gland of intermediate host; Biomphalaria pfeifferi.  Tanzanian Journal of Health Research http://www.bioline.org.br/abstract?id=th12041
- Eunice Nkirote Kobia, Horace Ochanda and Dorcas Syokui Yole (2012).The effect of immunizing Swiss white mice with snail soluble proteins and challenging them with Schistosoma mansoni. The Internet Journal of Tropical Medicine. Volume 8: Issue http://ispub.com/IJTM/8/1/14055
- Penina Njoki Muchirah, Dorcas  Yole, Hellen Kutima, Rebeccah Waihenya, Kennedy Muna Kuria and Mokua John (2012). Determination of effective praziquantel dose in different mouse strains: BALB/c and Swiss mice in treatment of Schistosoma mansoni. Journal of Clinical Immunolology and Immunopathology Research. 4(2):12-21. http://www.academicjournals.org/journal/JCIIR/article-abstract/F630DB55748
- Purity N. Nguhiu, Claire N. Wamae, Japheth K. Magambo, Paul G. Mbuthia, Daniel C. Chai, Dorcas S. Yole. (2012). "Gross and histopathological finding in Cercopithecus aethiops with experimental Cyclospora infection in Kenya".  Pathology and Laboratory Medicine International. 4: 1-8. http://erepository.uonbi.ac.ke/bitstream/handle/11295/14375/Abstract.PDF
- Susy Muchika, Helen Lydia Kutima, Rosebellah Orangi Maranga, Dorcas Syokui Yole. (2011). “Antischistosomal effects of Solanum incanum and Carica papaya crude extracts on the parasite Schistosoma mansoni in vivo and in vitro. The Internet Journal of Tropical Medicine ISSN:1540-2681. Vol 7(2) http://ispub.com/IJTM/7/2/7350
- Nguhiu P.N., Wamae C.N., Magambo J.K., Yole D.S. (2011). Prevalence and Intensity of Gastrointestinal Parasites in 65 Wild Trapped Pabio anubis (Olive Baboons) and 64 Cercopithecus aethiops (African green monkeys) in Kenya. The Kenya Veterinarian Vol.35 (1): 33-46. http://www.primateresearch.org/index.php/component/content/article/30-research-scientists/41-dr-dorcas-s-yole
- Moilo J.M., Mkoji G.M., Yole D.S. & Keriko J.M. (2014). Determination of Chenopodium ambrosoides  Crude Extracts on Worm Reduction, Gross Pathology & Histopathology in BALB/c Mice. Journal of Natural Science Research. Paper accepted for publication.
http://www.primateresearch.org/index.php/component/content/article/30-research-scientists/41-dr-dorcas-s-yole
- Naomi Waiganjo, Yole D, Ochanda H (2014). Antischistosomal activity of five plant extracts on Swiss white mice infected with Schistosoma mansoni. IORS Journalof Pharmacology and Biological Sciences. Vol.3(9):49-53 http://iosrjournals.org/iosr-jpbs/papers/Vol9-issue1/Version-6/J09164953.pdf
- Nguhiu P.N., Wamae C.N., Magambo J.K., Yole S.D. (2012). The African Green Monkey (Cercopithecus aethiops) as a non-human primate model for  infection with Cyclospora cayetanensis. Kenya Veterinarian Vol.36 (1)
http://www.ajol.info/index.php/kenvet/article/view/100553
- Moilo J.M., Yole D.S., Keriko J.M. & Mkoji G.M. (2014). Anti-schistosomal Activity of Chenopodium ambrosoides Extracts in Adult Worms in vivo and in vitro. Journal of Biology, Agriculture and Healthcare
http://www.iiste.org/vol-4-no-11-no-12-no-13-no-14-no-15-no-16-2014-journal-of-biology-agriculture-and-healthcare/
- John Mokua Mose, Helen L. Kutima, Susy Muchika, Rebeccah Wahihenya, Dorcas S. Yole (2012). The Evaluation of the effect of an Aqueous and Methanol extract of Solanum incanum and on Schistosoma mansoni infected mice. Asian Journal of Pharmaceutical and Health Sciences. Vol 2 (1): 278-282 http://www.primateresearch.org/index.php/component/content/article/30-research-scientists/41-dr-dorcas-s-yole
- Kanyugo, M.S., Ozwara H.S., W.T. Mutahi, D.S. Yole (2009). Parasitological and immunopathological responses in mice with concomitant Schistosoma mansoni and Plasmodium berghei infections: The Internet Journal of Tropical Medicine. Vol 5(2). http://ispub.com/IJTM/5/2/11017
- Mungatana N.W.K., Ngure, R.M., Shitandi, A.A., Mungatana C.K., Yole, D.S. (2009). Effect of experimental Schistosomiasis mansoni infection on serum levels of iron, zinc and copper in the olive baboon (Papio anubis). African Journal of Biochemistry Research.Vol 3(4): pp 107–114.
http://www.academicjournals.org/journal/AJBR/article-abstract/2CA822810541
- Muchemi G.M. & Yole D.S. (2008). Humane methods of capture and care of non-human primates for Conservation and Biomedical research. UON Proceedings of the Sixth Biennial Scientific Conference and Exhibition.
http://www.primateresearch.org/index.php/component/content/article/30-research-scientists/41-dr-dorcas-s-yole
- P.N. Nguhiu, C.N. Wamae, J.K. Magambo, J. Mulei, K. Kigthome and D.S. Yole (2008). Prevalence of acid-fast staining protozoa in wild-trapped Olive baboon (Papio anubis) from Aberdare Forest, Kenya. Proceedings of 2008 JKUAT Scientific Technological and Industrialization Conference. pp:251-256. http://www.primateresearch.org/index.php/component/content/article/30-research-scientists/41-dr-dorcas-s-yole
- M.M. Jeneby, M. Ngeiywa, D.S. Yole, J.M. Mwenda, M.A. Suleman, H.E. Carlson (2008). Enzootic simian piroplasm (Entopolypoides macaci ) in wild-caught Kenyan non-human primates. Journal of Medical Primatology. Journal of Medical Primatology. Vol 37: pp 329-336.
http://uu.diva-portal.org/smash/get/diva2:407540/FULLTEXT01.pdf
- Vincent K. Njoroge, Fred Nyundo, Moses Limo and Dorcas S. Yole (2007). A comparative study of Multiple versus Single infection doses of Schistosoma haematobium in Golden hamsters (Mesocricetus auratus). African Journal of Health Sciences Vol. 14 (3-4) 2007: pp. 187-194 http://www.bioline.org.br/abstract?jh07027
- D.S. Yole, Kennedy T. Shamala, K. Kithome, P.M. Wanjala and M. Gicheru (2007). Studies on interaction of Schistosomiasis mansoni and Leishmania major in experimentally infected BALB/c mice. (African Journal of Health Sciences).
http://www.primateresearch.org/index.php/component/content/article/30-research-scientists/41-dr-dorcas-s-yole
- NWK Mungatana, RM Ngure & DS Yole (2007). Acute Phase Response of Albumin and Haptoglobin in Experimental Infection of the Olive Baboon, Papio Anubis, with Schistosoma mansoni. Scandinavian Journal of Laboratory Animal Science.Volume 34 (2) http://www.sjlas.org/index.php/SJLAS/article/view/121
- Nancy W.K. Mungatana, S. M. Kariuki, Dorcas S. Yole, Raphael M. Ngure (2006). Assessment Of The Acute Phase Response In Experimental Infection Of Mice With Schistosoma Mansoni. The Internet Journal of Tropical Medicine. 2006. Volume 3 (1): 119-126. http://www.primateresearch.org/index.php/research/tropical-and-infectious-diseases/tropi-publications
- Dorcas S.Yole, Stephen K. Gikuru, Emmanuel O. Wango, Kiio Kithome, Simon Kiarie and Moses Limo (2006). Influence of age of mice on the susceptibility to murine schistosomiasis infection. African Journal of Health Sciences, 13 (1-2): 47-54 http://www.pubfacts.com/detail/17348743/Influence-of-age-of-mice-on-the-susceptibility-to-murine-schistosomiasis-infection
- Thomas M. Kariuki, Govert J. Van Dam, Andre M. Deelder, Idle O. Farah, Dorcas S. Yole, R. A. Wilson and Patricia S. Couson (2006). Previous or Ongoing Schistosome Infections Do not Compromise the Efficacy of the Attenuated Cercariae Vaccine. Infection and Immunity, 74(7): 3979-3986 http://www.ncbi.nlm.nih.gov/pubmed/16790771
- Dorcas S. Yole, Vincent O. Obanda., Kiio Kithome and Horace Ochanda (2005).The effect of vaccinating S. mansoni–infected BALB/c mice either before or after treatment. African Journal of Health Sciences, 12(3-4): 65-77.
http://www.ajol.info/index.php/ajhs/article/view/30802
- Kariuki TM, Farah IO, Yole DS, Mwenda JM, van Dam GJ, Wilson RA, Deelder, AM, Wilson, RA and Coulson PS (2004). Parameters of the attenuated schistosome vaccine evaluated in the olive baboon. Journal of Infectious Immunity, 72(9):5526-9. http://www.ncbi.nlm.nih.gov/pubmed/15322059
- Kariuki TM, Farah IO, Yole DS, van Dam GJ, Wilson RA, and Coulson PS (2003). Vaccination, chemotherapy and chronic schistosome infection: a complex interaction. American Journal of Tropical Medicine and Hygiene, 69 (3). Abstract. http://www.primateresearch.org/index.php/research/tropical-and-infectious-diseases/tropi-publications
- Farah I, Borjesson A, Kariuki T, Yole D, Suleman M, Hau J, Carlsso HE (2003). Morbidity and immune response to natural schistosomiasis in baboon (Papio anubis).  Parasitology Research. http://www.ncbi.nlm.nih.gov/pubmed/14574568
- Hastings Ozwara, Jan A.M. Langermans, Jeneby Maamun, Idle O. Farah, Dorcas S. Yole, Jason Mwenda, Horst Weiler and Alan W. Thomas(2003). Experimental Plasmodium knowlesi infection in the olive baboon (Papio anubis): severe disease is accompanied with cerebral involvement. American Journal of Tropical Medicine and Hygiene, 69 (2):188-94.
http://www.ncbi.nlm.nih.gov/pubmed/13677374
- M.A. Suleman., D. Yole., E. Wango., R. Sapolsky., K. Kithome., H.E. Carlsson and J. Hau (1999). Peripheral blood lymphocyte immunocompetence in wild African green monkeys (Cercopithecus aethiops) and the effects of capture and confinement. In vivo 70: 25-28. http://www.ncbi.nlm.nih.gov/pubmed/10218128
- D.S.Yole (1998).  A simple method of preparing clean intact granulomas and granuloma cells from livers of definitive hosts infected with either Schistosoma mansoni or Schistosoma japonicum. Acta Tropical 70: 233-237. http://www.ncbi.nlm.nih.gov/pubmed/9698270
- D.S. Yole., G.D.F. Reid and R.A. Wilson (1996).  Protection against Schistosoma mansoni and associated immune responses induced in the vervet monkey Cercopithecus aethiops by the irradiated cercariae vaccine.  Am. J. Trop. Med. Hyg. 54(13): 265-270. http://www.ncbi.nlm.nih.gov/pubmed/8600763
- D.S. Yole, R. Pemberton, G.D.F. Reid and R.A. Wilson (1996).  Protective immunity to Schistosoma mansoni induced in the olive baboon Papio anubis by the irradiated cercariae vaccine.  Parasitology 112: 37-46.
http://www.ncbi.nlm.nih.gov/pubmed/8587800
CURRENT POSTGRADUATE STUDENTS SUPERVISION
Name Project Title Period
Darlene Nyaboke AyongaMSc Applied Parasitology, University of Nairobi2012
Lynda Audrey AllanMSc Zoology (Immunology), Jomo Kenyatta University of Agriculture and Technology2014
Benjamin KimeuMSc in Biochemistry, Kenyatta University2014
Margaret Gacwe KindikiMSc Applied Parasitology, University of Nairobi2014
Elizabeth SyombuaMSc Parasitology, Jomo Kenyatta University of Agriculture and Technology2014
Lydiah MoseMSc Applied Parasitology, University of Nairobi2013
Agnes Ikolot OtwaniMSc Applied Parasitology. Kenyatta University. On going
Esther KagasiMSc Medical Laboratory Science Mount Kenya University.On going
Victor Odhiambo MageroMSc Medical Laboratory Science, Mount Kenya UniversityOn going
Dorothy OpondoMSc Degree in Applied Parasitology, University of Nairobi2010
Penina Njoki MuchirahMSc Immunology, Jomo Kenyatta University of Agriculture and Technology2010
Mokua John MoseMSc Immunology, Jomo Kenyatta University of Agriculture and Technology2011
Michael OduorMSc Parasitology, Jomo Kenyatta University of Agriculture and Technology2011
Susy MuchikaMSc Parasitology, Jomo Kenyatta University of Agriculture and Technology2010
Kennedy MunaMSc Immunology, Jomo Kenyatta University of Agriculture and Technology2011
Edward Owiti OkonjoMSc Applied Parasitology, University of Nairobi2010
Eunice KobiaMSc Applied Parasitology, University of Nairobi2011
Linda AlilaMPhil Public Health, Yale School of Public Health2008
Sarah KanyugoMSc Applied Parasitology, University of Nairobi2008
Kithome KiioMSc Applied Parasitology, Kenyatta University2009
Vincent NjorogeMSc Biochemistry, Egerton University2007
Nancy KariukiMSc Biochemistry, Egerton University2006
Ombaso OketchMSc Applied Parasitology, University of Nairobi.2007
Bernedette MukongoloMSc Applied Parasitology, University of Nairobi2007
Humphrey KariukiMPhil Parasitology, University of Nairobi. 2005
Vincent O. ObandaMPhil Parasitology, University of Nairobi2005
Stephen GikuruMSc Biochemistry, Egerton University2000
Rhoda Rehema ChaiPhD (Biology), The Technical University of Kenya. Project title “Use of Geospatial Techniques to map the distribution of vervet monkeys in urban areas: Case study, Nairobi County. Proposal defended on 3rd December, 2014. Funded by NACOSTI in 2015.2014
Lynda AllanPhD (Biomedical Sciences), The Technical University of Kenya. Project title “Assessment of Paediatric Intesttinal Nematodes Infestation on Immunological Responses to Pneumococcal Conjugate Vaccine. Proposal defended on 2nd December, 2014. Applying for funding.2014
Edward OkonjoPhD (Biology), The Technical University of Kenya. Project title “Intergrated schistosomiasis control-a case study of Mwea irrigation scheme, Kenya”. (Proposal approved in 2012; Project funded by NACOSTI in June 2014; work ongoing).2014
Anastacia NzauPhD (Biology),The Technical University of Kenya. Project title “Integrated control of Leishmaniasis in Baringo District, Kenya”. (Proposal approved in 2013; Work ongoing. Funded by NACOSTI, 2015).2015
Benter OnyangoPhD (Biology) The Technical University of Kenya. Project title “Evaluation of larvicidal activity of plant fractions towards development of biopesticide” (Proposal approved in 2012; Project funded by NACOSTI in June 2014; Work ongoing).2014
Tom OsebePhD (Zoology), University of Nairobi. Project title “Chemical characterization of four antischistosomal plant extracts from Kenya”. (2012); DAAS Scholar; Project funded by NCST, finalizing project).2012
Eunice KobiaPhD (Zoology), University of Nairobi. Project title “Immunizing the Olive Baboon, Papio anubis, with Snail Soluble Proteins, RT & DG”. (2012; Finalizing project).2012
Kennedy MunaPhD (Medical Laboratory Sciences) Mount Kenya University. Project title “Characterization of Biomphalaria pfeifferi soluble proteins that offer protection against Schistosoma mansoni in BALB/c Mice.” (Proposal approved in 2011; Project funded by NACOSTI in June 2014; Finalizing project).2011
Susy MuchikaPhD (Parasitology), Jomo Kenyatta University of Agriculture & Technology “Evaluation of Antischistosomal and Molluscicidal Activity of Selected Medicinal Plants in Kenya”. (2011: Finalizing project2011
Joseph MoiloPhD (Medical Parasitology & Entomology), Jomo Kenyatta University of Agriculture and Technology (Institute of Tropical Medicine and Infectious Diseases - ITROMID). Project title “Efficacy of crude preparation and extracts of Chenopodium ambrosoides against Schistosoma mansoni infection in BALB/c mice”. (2006) 2 papers published; 1 paper accepted for publication. Thesis submitted.2006
Naomi WaiganjoPh (Zoology) University of Nairobi, Project title “Antischistosomal effects of extracts of selected plants on BALB/c mice infected with Schistosoma mansoni”. (2010). Graduated in 2012. 3 Papers published2012
Purity NguhiuPhD (Medical Parasitology & Entomology), Jomo Kenyatta University of Agriculture and Technology (Institute of Tropical Medicine and Infectious Diseases - ITROMID). Project title “Clinical-Epidemiologicy of Cyclospora spp in Kenyan Non-human primates: A laboratory model for cyclosporiasis” (2008). Graduated in 2012. 4 Papers published.2012
COURSES TAUGHT
Course Name Brief Description Period
Medical Parasitology (Protozoology, Helminthology and Vector Biology)parasites of medical importance and the organisms which spread them2010 - 2012
Immunologymechanisms of body defence against infectious agents2007 - 2008
Parasitologysingle celled and multicellular parasites which cause infections2007 - 2008
Parasitologysingle celled and multicellular parasites which cause infections2007 - 2008
Laboratory Animals Animals used in the laboratory for experiments2007 - 2008
Applied Immunology & Vaccine Design Body defence mechanism and immunological interventions to the infections2002 - 2012
Parasite Physiology & Principles of Chemotherapy parasite structure and functions and how these can be utilized in development of drugs2002 - 2012
ImmunologyBody defence mechanisms against infectious agents2002 - 2012
Physical Sciences Chemistry and Physics1998 - 2003
Introduction to Biological Sciences Introduction to Biological Sciences 1998 - 2003
Immunologyprinciples of Immunology and advanced Immunology2012 - TO-DATE
Medical Entomology & Protozoology organisms which aid in spreading infections and the single celled infectious parasites.2010 - 2011
PROFESSIONAL AFFILIATIONS AND SOCIETIES
Associate Research Scientist, Institute of Primate Research

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