PROF ALFRED ORINA ISAAC :: :: STAFF EPORTAL - THE TECHNICAL UNIVERSITY OF KENYA

Faculty:	Applied Sciences and Technology
School:	HEALTH AND BIOMEDICAL SCIENCES
Department:	Pharmaceutical Sciences and Technology
Current Designation:	Deputy Vice-chancellor , RESEARCH AND TECHNOLOGY DEVELOPMENT (RTD)
Office Telephone:	0725423150
Official Email:	alfred.orina@tukenya.ac.ke
Consultation Hours:	8.00am-05pm,Mon-Fri

Level	Qualification Name	Institution	Year
Doctor of Philosophy (PhD)	Phamaceutical Science	Idaho State University(United States)	2007
Masters of Science (M.Sc.)	Biochemestry and Mole Biology	EGERTON UNIVERSITY(Kenya)	2000
Bachelor of Science (BSc)	Chemistry & Biochemistry	EGERTON UNIVERSITY(Kenya)	1996

Period	Institution	Position
2002 - 2007	Case Western Reserve university Medical centre and university hospitals	Post-doctoral associate scientist(Neuroscience)
2002 - 2007	Collage of Phamacy,Idaho staetes University	Research Assistant
2011 - *	Technical University of Kenya	Senior Lecturer
1997 - *	Nyanchw Adventist High School	High School Science and Maths teacher

Title	Link to pulication
Coenzyme Q10 Ameliorates Potassium Cyanide-Induced Toxicosis in a Mouse Model	https://doi.org/10.1016/j.sciaf.2021.e00815
Coenzyme Q10 protected against arsenite and enhanced the capacity of 2,3-dimercaptosuccinic acid to ameliorate arsenite-induced toxicity in mice	https://doi.org/10.1186/s40360-021-00484-z
Manganese exacerbated chronic khat-induced neurological deficits, inflammation and organ toxicity in a mouse model	https://doi.org/10.1007/s13530-021-00091-9.
Coenzyme Q10 nullified khat-induced hepatotoxicity, nephrotoxicity and inflammation in a mouse model	https://doi.org/10.1016/j.heliyon.2020.e04917
Scientific Writing for Students and Young and Scientists	https://www.amazon.com/Scientific-Writing-Students-Young-Scientists/dp/151428961X
Coenzyme Q10 and cerebral malaria in mice: Questionable interpretations, improbable usefulness in humans	https://doi.org/10.1016/j.parint.2019.101970
Oral administration of Coenzyme Q 10 protects mice against oxidative stress and neuro-inflammation during experimental cerebral malaria	https://doi.org/10.1016/j.parint.2019.04.010
Coenzyme Q10 Protect Mice Against Inflammatory Responses During Experimental Cerebral Malaria	https://www.iiste.org/Journals/index.php/JNSR/article/view/46051/47720
Oral administration of coenzyme Q10 has the capacity to stimulate innate lymphoid cells class two during experimental cerebral malaria	http://10.9734/SAJP/2019/46442
Coenzyme Q10 and endogenous antioxidants neuro-protect mice brain against deleterious effects of melarsoprol and Trypanasoma brucei rhodesiense	https://www.iiste.org/Journals/index.php/JNSR/article/view/41230
Prevalence and Concentration of Lead (Pb) and Cadmium (Cd) in Kales (Brassica oleracea Acephala) & Spinach (Spinacia oleracea) Sold at Masaku County, Kenya	https://www.sciencepublishinggroup.com/journal/paperinfo?journalid=614&doi=10.11648/j.ijfsb.20200504.16
Kenyan purple tea anthocyanins and coenzyme-Q10 ameliorate post treatment reactive encephalopathy associated with cerebral human African trypanosomiasis in murine model	http://10.1016/j.parint.2014.01.001.
Chronic mitochondrial DNA depletion in peripheral neural cell lines and its implications in peripheral neuropathy	https://go.gale.com/ps/i.do?id=GALE%7CA362273375&sid=googleScholar&v=2.1&it=r&linkaccess=fulltext&issn=05363012&p=AONE&sw=w&userGroupName=anon%7E29dc8f1a
Coenzyme Q10 prevented full blown splenomegaly and decreased melarsoprol-induced reactive encephalopathy in mice infected with Trypanosoma brucei rhodesiense	http://10.12980/jclm.2.2014c903
Kenyan purple tea anthocyanins ability to cross the blood brain barrier and reinforce brain antioxidant capacity in mice	http://10.1179/1476830513Y.0000000081
Antifungal activity of crude tea extracts	https://doi.org/10.5897/AJAR2013.6742
Sex-specific induction of CYP6 cytochrome P450 genes in cadmium and lead tolerant Anopheles gambiae	https://doi.org/10.1186/1475-2875-12-97
Reduced glutathione regenerating enzymes undergo developmental decline and sexual dimorphism in the rat cerebral cortex	https://doi.org/10.1016/j.brainres.2009.05.029
Abnormal brain iron homeostasis in human and animal prion disorders	http://10.1371/journal.ppat.1000336.
Prion protein modulates cellular iron uptake: a novel function with implications for prion disease pathogenesis	http://10.1371/journal.pone.0004468
Effects of continuous hypoxia on energy metabolism in cultured cerebro-cortical neurons	https://doi.org/10.1016/j.brainres.2008.06.074
Metabolic and antioxidant system alterations in an astrocytoma cell line challenged with mitochondrial DNA deletion	http://10.1007/s11064-007-9380-3
Manganese treatment modulates the expression of peroxisome proliferator-activated receptors in astrocytoma and neuroblastoma cells	http://10.1007/s11064-006-9173-0
Isolation and biochemical characterization of transferrin from the tsetse fly, Glossina morsitan centralis	https://doi.org/10.4314/ejbmb.v23i2.35910

Download Profile